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All Posts in Category: Services

Preimplantation Genetic Screening (PGS)

PGS (Preimplantation Genetic Screening)

Preimplantation Genetic Screening

Since the study of produced embryos in vitro revealed a high rate of chromosomal aneuploidy. Most types of aneuploidy are not compatible with life, regarding these most common syndromes caused by non-sex chromosome aneuploidy including Down syndrome, Edwards syndrome, and Patau syndrome.

Aneuploidy is usually not inherited and can involve any chromosome. In addition, the embryos that derived from advanced reproductive age mothers have significant incident of chromosomal mutation.

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EmbryoScope Plus

EmbryoScope Plus the tracing of embryo’s development. 

EmbryoScope Plus is a special cabinet for embryo. The capability of the tank is the combination of usual culture tank – the stereo microscope and Leica’s lenses camera within one machine and this advantage gives the high quality of photos. Furthermore, the technology ‘time lapse’ continuously monitors the embryo development during culturing in the cabinet.

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MACS Sperm

What is MACS Sperm?

MACS is a method to select a non-apoptotic sperm. Apoptotic or apoptosis-like manifestation sperm have an externalized phosphatidylserine (EPS) on sperm surface, EPS is a marker of apoptotic or apoptosis-like manifestation sperm which have a DNA damage or sperm DNA fragmentation. DNA damage will lead sperm to have programmed cell death. There are many factors that have effect to sperm DNA such as environmental and life style factors, systemic diseases, or primary cause of male reproductive tract.

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Getting Started IVF Step-by-Step at Safe Fertility Center

Getting Started; IVF Step-By-Step

Getting Started; IVF Step-By-Step at SAFE Fertility Center

1. Ovarian Stimulation

After blood test and scan have been done on Day 2-3 of your menstruation period, the doctor will prescribe the medicines for injection via abdomen to stimulate your eggs which takes around 10-12 days. You can bring the medicine back home, and only one appointment with the doctor.

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IMSI by Leica - Safe Fertility Center

IMSI (Intra-cytoplasmic Morphologically Selected Sperm Injection)

Intra-cytoplasmic Morphologically Selected Sperm Injection (IMSI) high magnification ICSI

IMSI is a real-time method where sperms are selected before the microinjection takes place. This is done using an inverted microscope that is able to provide a much greater magnifying power (around 6,000 times) than those that are normally used in reproductive laboratories (400 times) to carry out the ICSI.

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Verifi Prenatal Test (NIPT)

Verifi Prenatal Test (Non-invasive prenatal testing for down syndrome screening)

Verifi Prenatal Test is a simple blood test that screens for the most common chromosomal abnormalities that can affect your baby’s future health. A sample can be drawn in your doctor’s office as early as the 10th week of pregnancy, and it may help you avoid more invasive procedures, such as amniocentesis or chorionic villus sampling (CVS), which are not without risks to you and your baby. The verifi® test is available for both singleton and twin pregnancies.

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Genetic Testing

Genetic testing

I. Overview of PGD

A. Preimplantation Genetic Diagnosis (PGD) for aneuploidy screening
Preimplantation genetic diagnosis is scientific technique, which is developed to test the embryos for specific diseases or screening of chromosome abnormalities. In IVF, 30 – 70% of embryos have chromosomal aneuploidy. PGD can be used to improve the success rate for infertile couples, by selection of the most suitable embryos to transfer.

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illumina-NGS (Next-Generation Sequencing)

illumina-NGS (Next-Generation Sequencing)

Regarding better feasibility and less time consuming for testing than previous techniques, aCGH, SNPs and qPCR are the common technology that has been widely use for PGS worldwide. The potential applications of PGS have been expanded dramatically with the easy availability of sequence-based information on chromosomal abnormalities through pathologic genes responsible for inherited diseases.

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Embryo transfer

Embryo Transfer (ET)

Embryo Transfer procedure is the last one of the in vitro fertilization process.

Embryos may be transferred anytime between day 1 through day 5 after the retrieval of the eggs depending on individuals’ condition. Embryos can be either “fresh” from fertilized egg cells of the same menstrual cycle, or “frozen”, that is they have been generated in a preceding cycle and undergone embryo cryopreservation, and are thawed just prior to the transfer, which is then termed “frozen embryo transfer” (FET).

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