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All Posts in Category: Fertility Treatment

Preimplantation Genetic Screening (PGS)

PGS (Preimplantation Genetic Screening)

Preimplantation Genetic Screening

Since the study of produced embryos in vitro revealed a high rate of chromosomal aneuploidy. Most types of aneuploidy are not compatible with life, regarding these most common syndromes caused by non-sex chromosome aneuploidy including Down syndrome, Edwards syndrome, and Patau syndrome.

Aneuploidy is usually not inherited and can involve any chromosome. In addition, the embryos that derived from advanced reproductive age mothers have significant incident of chromosomal mutation.

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MACS Sperm

What is MACS Sperm?

MACS is a method to select a non-apoptotic sperm. Apoptotic or apoptosis-like manifestation sperm have an externalized phosphatidylserine (EPS) on sperm surface, EPS is a marker of apoptotic or apoptosis-like manifestation sperm which have a DNA damage or sperm DNA fragmentation. DNA damage will lead sperm to have programmed cell death. There are many factors that have effect to sperm DNA such as environmental and life style factors, systemic diseases, or primary cause of male reproductive tract.

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IMSI by Leica - Safe Fertility Center

IMSI (Intra-cytoplasmic Morphologically Selected Sperm Injection)

Intra-cytoplasmic Morphologically Selected Sperm Injection (IMSI) high magnification ICSI

IMSI is a real-time method where sperms are selected before the microinjection takes place. This is done using an inverted microscope that is able to provide a much greater magnifying power (around 6,000 times) than those that are normally used in reproductive laboratories (400 times) to carry out the ICSI.

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Genetic Testing

Genetic testing

I. Overview of PGD

A. Preimplantation Genetic Diagnosis (PGD) for aneuploidy screening
Preimplantation genetic diagnosis is scientific technique, which is developed to test the embryos for specific diseases or screening of chromosome abnormalities. In IVF, 30 – 70% of embryos have chromosomal aneuploidy. PGD can be used to improve the success rate for infertile couples, by selection of the most suitable embryos to transfer.

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illumina-NGS (Next-Generation Sequencing)

illumina-NGS (Next-Generation Sequencing)

Regarding better feasibility and less time consuming for testing than previous techniques, aCGH, SNPs and qPCR are the common technology that has been widely use for PGS worldwide. The potential applications of PGS have been expanded dramatically with the easy availability of sequence-based information on chromosomal abnormalities through pathologic genes responsible for inherited diseases.

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Embryo transfer

Embryo Transfer (ET)

Embryo Transfer procedure is the last one of the in vitro fertilization process.

Embryos may be transferred anytime between day 1 through day 5 after the retrieval of the eggs depending on individuals’ condition. Embryos can be either “fresh” from fertilized egg cells of the same menstrual cycle, or “frozen”, that is they have been generated in a preceding cycle and undergone embryo cryopreservation, and are thawed just prior to the transfer, which is then termed “frozen embryo transfer” (FET).

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Trophectoderm Biopsy

1) What is trophectoderm biopsy? 

Once the embryos have reached the blastocyst stage on the fifth or sixth day of development, the trophectoderm cells, which will be destined to be placenta, are removed. The removed cells can be tested for comprehensive chromosomal screening (CCS) or specific genetic diseases.

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IUI, การผสมเทียมโดยการฉีดอสุจิเข้าสู่โพรงมดลูกโดยตรง

Intrauterine insemination (IUI)

Intrauterine insemination (IUI) is a procedure which prepared sperm is placed in the womb close to the time of ovulation. The semen is prepared to separate fast moving sperm from sluggish or non-moving sperm.

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Embryo Freezing by SAFE

Embryo Freezing (Embryo Cryopreservation)

Embryo Freezing (Embryo Cryopreservation)

If there are leftover embryos (of sufficient quality) beyond the number that is transferred, many couples prefer to have them frozen (Cryopreserved) for use in a future cycle.  

Embryo Freezing (Embryo cryopreservation) can be used for another attempt at having a baby if the “fresh” cycle fails or as an attempt to have another child if the fresh cycle is successful.

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