Miscarriage or abortion is used to describe a pregnancy that fails to progress, resulting in death and expulsions of the embryo or fetus. According to Thai laws, the birth before 28 weeks of gestation is classified as an abortion.
Recurrent miscarriage should be defined, according to the above definition of miscarriage, as at least three consecutive miscarriages.
What causes of recurrent miscarriage?
- Chromosomal abnormalities: The abnormalities may be the extra or missing of the whole chromosome or some part of chromosome, resulting in the death of fetus.
- Uterine abnormalities: Distortion of the uterine cavity is one of the causes of recurrent miscarriage. These abnormalities may be congenital, such as septate uterus, or acquired, such as myoma uteri.
- Abnormalities of uterine cervix. The weakened cervix cannot support the pregnancy until term because of the weight of the growing baby. Abortion usually occurs in the 2nd trimester of pregnancy.
- Hormonal abnormalities: Progesterone, a hormone produced by the ovary after ovulation, is necessary for a healthy pregnancy. Luteal phase deficiency is one of the cause of recurrent miscarriage.
- Antiphospholipid syndrome: Antiphospholipid syndrome is an autoimmune disorder that the body makes antibodies mistakenly attack self phospholipids and proteins. This damage causes blood clots to form in the body’s vessels, resulting in recurrent pregnancy loss and preterm delivery.
- Other medical diseases: such as Systemic Lupus Erythromatosus (SLE) or thyroid disorder.
- Unexplained: No explanation is found in 50-75% of couples with recurrent miscarriage.
Many professional organizations have the recommendation to find out the causes of recurrent miscarriage. After the prevention or treatment, those couples will have a higher chance to get pregnant until term and give birth with a healthy child.