Since the study of produced embryos in vitro revealed a high rate of chromosomal aneuploidy. Most types of aneuploidy are not compatible with life, regarding these most common syndromes caused by non-sex chromosome aneuploidy including Down syndrome, Edwards syndrome, and Patau syndrome.
Aneuploidy is usually not inherited and can involve any chromosome. In addition, the embryos that derived from advanced reproductive age mothers have significant incident of chromosomal mutation.
Boosting your IVF Pregnancy and Live birth success rates
Increasing your IVF success rate
An essential step for successful IVF outcome is the selection of high-quality embryos for transfer. With this thought in mind, we have been using the exclusive methods and the latest technologies for the better quality of your embryos.
Next Generation Sequencing (NGS)
Next Generation Sequencing (NGS) – Safe Fertility Center
The human body is made up of several organ systems all working together as a unit to make sure the body keeps functioning. These organs are different in each person both in anatomy and functions due to genes and DNA. There are significantly differentiations between the sets of DNA in a person with and without Chromosomal abnormality. Next generation sequencing technology (NGS) is the latest technology developed to identify the abnormality in DNA which has been adapted for chromosome screening of embryo. Because of its accurate, effective and fast result, NGS can help improve the success rate of clinical pregnancy; especially in the cases of patients with repeated miscarriage, with age higher than 28 years old, or with repeated IVF failure.
is an incubator that maintains the necessary physiological conditions required by a living embryo while they are in the IVF laboratory. It has an incorporated time lapse system that has a camera that continuously captures images and records them as a video of the embryonic development. With this information, the embryologist can select the best embryo for transfer. Furthermore, we have been using embryo glue and atosiban to improve the effective of embryo implantation, consequently, increase the success of your clinical pregnancy rate.
EmbryoGlue consisted of Hyaluronic acid helps the embryo to implant by increasing the adhesion of the embryo to the endometrium. Compared to patients who transfer without embryo glue, those with EmbryoGlue have a higher rate of clinical pregnancy around 7% or 1.5 times.
Oxytocin Antagonist (Atosiban)
is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant to halt premature labor which can to improve the clinical pregnancy rate significantly. Planning for treatment and embryo transfer depends on each patient’s problem and difficulty; therefore, it is suggested for the patient to consult carefully with the doctor for the best outcome.
A. Preimplantation Genetic Diagnosis (PGD) for aneuploidy screening
Preimplantation genetic diagnosis is scientific technique, which is developed to test the embryos for specific diseases or screening of chromosome abnormalities. In IVF, 30 – 70% of embryos have chromosomal aneuploidy. PGD can be used to improve the success rate for infertile couples, by selection of the most suitable embryos to transfer.
Regarding better feasibility and less time consuming for testing than previous techniques, aCGH, SNPs and qPCR are the common technology that has been widely use for PGS worldwide. The potential applications of PGS have been expanded dramatically with the easy availability of sequence-based information on chromosomal abnormalities through pathologic genes responsible for inherited diseases.