How woman’s age, egg’s quality, number of retrieved eggs, womb, sperms and the method of embryo transfer affect IVF success rate?
To determine the chance of getting a healthy baby, the key factors are woman’s age, egg’s quality, number of retrieved eggs, womb, sperms and the method of embryo transfer (fresh or frozen).
In good prognosis group of patients, especially in young age patients, transferring embryo—whether it be fresh or frozen—yields similar outcomes in pregnancy. However, there is a question often asked concerning the amount of eggs required for the highest success rate, resulted in the meta-analysis of 17 years worth of data (from 1991 – 2008) had been conducted and published in 2014. With an analysis of 400,135 treatment cycles, the following are what had been found; Association between the number of eggs and live birth in fresh embryo transfer
|Age||Number of cycles (%)|
|Less than 35 years old||200,982 (50.2)|
|35 – 37 years old||97,345 (24.3)|
|38-39 years old||51,358 (12.8)|
|More than 40 years old||50,423 (12.6)|
In this study, the median number of eggs retrieved was 9 and the median number of embryos created was 5. There was a strong association between the number of eggs and the live birth rates which rose with increasing number of eggs up to 15, plateaued between 15 and 20 eggs and steadily declined beyond 20 eggs The best chance of live birth was associated with the number of eggs of around 15. The number of eggs more than 18 makes no difference to the number of embryos created. Nowadays, mild ovarian stimulation tends to be used to treat with a good prognosis group of patients because of the good outcome and the less use of medicines.
(Obstetrician and Gynecologist Subspecialty in Reproductive Medicine)